類器官Y-27632 dihydrochloride

簡要描述：類器官Y-27632 dihydrochloride
類器官（Organoids）是指將成體干細胞或多能干細胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構的組織類似物。類器官在組織結(jié)構、細胞類型、自我更新能力和功能等方面與來源組織高度一致，從而在發(fā)育生物學、疾病造模、精準醫(yī)學、藥物研發(fā)、基因和細胞療法、感染和免疫以及再生醫(yī)學等生物醫(yī)學的多個領域展現(xiàn)出*的優(yōu)勢。

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更新時間：2025-06-26
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類器官Y-27632 dihydrochloride

類器官（Organoids）是指將成體干細胞或多能干細胞在體外三維培養(yǎng)形成的具有一定空間結(jié)構的組織類似物。類器官在組織結(jié)構、細胞類型、自我更新能力和功能等方面與來源組織高度一致，從而在發(fā)育生物學、疾病造模、精準醫(yī)學、藥物研發(fā)、基因和細胞療法、感染和免疫以及再生醫(yī)學等生物醫(yī)學的多個領域展現(xiàn)出*的優(yōu)勢。

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Background

Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation^{[1][2][3][4][5]}.

技術參數(shù)

M. W t	320.26
Formula	C₁₄H₂₃Cl₂N₃O
CAS No	129830-38-2
Storage	Powder	-20 °C	3 years
	In solvent	-80°C	6 months
		-20 °C	1 month
Solubility	DMSO	33.33 mg/mL(104.07 mM; Need ultrasonic)
	H₂O	100 mg/mL(312.25 mM; Need ultrasonic)

BIOLOGICAL ALTIVITY
In Vitro
Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively^[1].
Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 μM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 μM Y-27632 induced group^[2].
In Vivo
Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group^[3].
Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)^[4].